TrailBio Tranylcypromine Hemisulfate

TrailBio® Tranylcypromine Hemisulfate

$100.00

Irreversible MAO and LSD1 inhibitor 

  • Irreversible inhibitor of monoamine oxidases (MAO-A and MAO-B) and lysine-specific demethylase 1 (LSD1/KDM1A). 
  • Inhibits monoamine metabolism and LSD1-mediated H3K4 demethylation, modulating monoamine availability and epigenetic gene regulation. 
  • Used to study monoamine metabolism, epigenetic regulation, cellular differentiation and transcriptional control. 
Bulk, Academic or Special Pricing
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Description

Technical Information & Resources

Publications

Additional Information

Technical Information & Resources

Supporting Publications

Schmidt & McCafferty (2007), Biochemistry 

  • Shows tranylcypromine irreversibly inactivates LSD1 by covalently modifying its FAD cofactor, while inhibiting MAO-B and MAO-A more potently than LSD1. 

Lee et al. (2006), Chem Biol 

  • Identifies tranylcypromine as the most potent LSD1 inhibitor among the MAO inhibitors tested. In P19 embryonal carcinoma cells, it raised global H3K4 methylation and switched on LSD1 target genes, including Oct4. 

Li et al. (2009), Stem Cells 

  • Combined with the GSK-3 inhibitor CHIR-99021, tranylcypromine (Parnate) enabled reprogramming of human primary keratinocytes with only Oct4 and Klf4, the first human iPSCs generated from somatic cells without exogenous Sox2. 

Additional information

Chemical Name

trans-2-phenylcyclopropylamine sulfate
CAS Number

13492-01-8
Purity

≥98%
Formula

C9H12NO2S0.5
Molecular Weight

182.23 g/mol
Usage

For research use only
Storage (Solid)

4 °C for up to 2 years, sealed storage, keep away from moisture
Storage (Solution)

-80 °C for up to 1 year or -20 °C for up to 6 months
Form

Powder
Shipping

Ambient temperature

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