TrailBio® SP600125

$100.00

Small-molecule inhibitor of c-Jun N-terminal kinase (JNK)

  • Reversible, ATP-competitive JNK inhibitor that blocks c-Jun phosphorylation.
  • Small-molecule component of chemical cell-conversion media, used alongside other pathway modulators.
  • Routinely used in studies that relate to cellular responses to stress and inflammation.
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Description

Technical Information & Resources

Supporting Publications

Bennett et al. (2001), PNAS

  • Identifies SP600125 as a reversible, ATP-competitive inhibitor of JNK1, JNK2, and JNK3 with >20-fold selectivity versus a range of kinases tested, and shows it inhibits c-Jun phosphorylation in cells.

Wan et al. (2018), Int J Mol Med

  • Used SP600125 as one of seven small molecules (valproic acid, CHIR99021, DMH1, Repsox, forskolin, Y-27632, SP600125) to convert human lung fibroblasts (MRC-5) into neuronal cells, with ~90% Tuj1-positive cells after 7 days.

Additional information

Chemical Name

anthra[1,9-cd]pyrazol-6(2H)-one

CAS Number

129-56-6

Purity

≥98%

Formula

C14H8N2O

Molecular Weight

220.23 g/mol

Usage

For research use only

Storage (Solid)

20 °C for up to 3 years or 4 °C for up to 2 years

Storage (Solution)

-80 °C for up to 2 years or -20 °C for up to 1 year

Form

Powder

Shipping

Ambient temperature