TrailBio® SAG

$100.00

Smoothened (Smo) Agonist for Hedgehog Pathway Activation

  • Binds and activates Smoothened (Smo), the key transducer of Hedgehog (Hh) pathway signaling.
  • Induces Smo internalization and GLI transcription factor activation, driving Hh target gene expression.
  • Used in iPSC neural patterning, ventral neural progenitor specification, and organoid protocols requiring Hh pathway activation.
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Description

Technical Information & Resources

Supporting Publications

Chen et al. (2002), PNAS

  • The original paper identifying SAG as a Smo agonist that binds the heptahelical bundle and antagonizes cyclopamine.

Wang et al. (2014), Nature Communications

  • Crystal structure of human SMO bound to a SAG analog (SAG1.5), showing the conformational rearrangement underlying Smo activation.

Klein et al. (2022), Frontiers in Cellular Neuroscience

  • Uses SAG to modulate Shh signaling in iPSC-derived neural progenitor cells, rescuing lineage specification defects.

Additional information

Chemical Name

3-Chloro-N-[(1r,4r)-4-(methylamino)cyclohexyl]-N-[3-(pyridin-4-yl)benzyl]benzo[b]thiophene-2-carboxamide

CAS Number

912545-86-9

Purity

≥98%

Formula

C28H28ClN3OS

Molecular Weight

490.06 g/mol

Usage

For research use only

Storage (Solid)

4 °C for up to 2 years, protect from light

Storage (Solution)

-80 °C for up to 2 years or -20 °C for up to 1 year, protect from light

Form

Powder

Shipping

Ambient temperature