About Trailhead Biosystems

The iPSC technology by Dr. Yamanaka and colleagues opened many entryways into studying human disease in entirely novel ways. At Trailhead Biosystems, we are driven by the fundamental belief that there is only one human biology – an evolutionarily formed system consisting of a vast, yet stable set of unique cell states. These precise cell states are essential for the proper functioning of every organ in the human body, emerging through tightly controlled processes during early embryonic development. 

However, due to the immense complexity of cell signaling networks, it has historically proven incredibly challenging, if not impossible, to control the formation and behavior of human cells outside the body. Unlocking the ability to guide cells into desired states would open up transformative possibilities across biomedicine. 

This motivated our team of scientists and engineers to pioneer a revolutionary discovery approach that greatly amplifies our ability to experimentally test and understand these intricate biological systems.  

Our proprietary High-Dimensional Design of Experiment (HD-DoE) technology platform is the key to unlocking this potential. By leveraging advanced computational models and precision control systems, we can meticulously orchestrate the intricate signaling pathways and environmental cues that govern natural developmental biology. This allows us to direct the differentiation of iPSCs with unprecedented precision and efficiency. 

We can transform any hiPSC line into virtually any desired cell type imaginable. We may not have made a protocol for all the human cells yet – but Trailhead is the company that can do it.