TrailBio^® Gö6983

Gschwendt et al. (1996), FEBS Lett 

• Shows Gö6983 potently suppresses kinase activity of PKC isoenzymes from all three subgroups, while only weakly inhibiting PKCμ (IC50 20 µM). 

Takashima et al. (2014), Cell 

• Shows that combined ERK and PKC inhibition, using Gö6983, stably maintains naive, ground-state human pluripotent stem cells without transgenes. 

Gafni et al. (2013), Nature 

• Establishes defined naive human conditions (NHSM), which include Gö6983, for deriving naive pluripotent stem cells from primed ESCs, iPSC reprogramming or blastocysts.