TrailBio^® Dexamethasone

Tsurufuji S et al. (1979), Nature

• Directly investigated the anti-inflammatory mechanism of dexamethasone through the glucocorticoid receptor and gene expression.

Jaiswal et al. (1997), J Cell Biochem

• Demonstrated optimal osteogenic differentiation over 16 days with 100 nM dexamethasone, 0.05 mM ascorbic acid-2-phosphate and 10 mM β-glycerophosphate.

Ahlström et al. (2009), Steroids

• Shows that 10 nM dexamethasone increased mineralization and expression of the osteoblast markers Runx2 and alkaline phosphatase in adult human mesenchymal stem cells, with glucocorticoid receptor involvement shown using the antagonist mifepristone.