TrailBio^® A 83-01

Tojo et al. (2005), Cancer Science

• Foundational paper synthesizing and characterizing A 83-01 as a potent ALK4/ALK5/ALK7 inhibitor that blocks TGF-β-induced SMAD2/3 phosphorylation and epithelial-to-mesenchymal transition.

Li et al. (2009), Cell Stem Cell

• Stem cell study using A 83-01 with PD0325901 (Cat No. TB27940) and CHIR99021 (Cat No. TB54925) to support the generation and long-term maintenance of rat and human iPSCs.

Gurung et al. (2015), Scientific Reports

• Human stem/stromal cell study showing that A 83-01 inhibits SMAD2/3 signaling, promotes endometrial mesenchymal stem/stromal cell proliferation, and reduces senescence and apoptosis while maintaining functional differentiation capacity.