Description
Technical Information & Resources
Supporting Publications
- This foundational paper established that inhibition of ERK signaling with PD0325901, together with GSK3 inhibition, supports mouse embryonic stem cell self-renewal and pluripotency maintenance.
Silva et al. (2008), PLOS Biology
- Study shows that MEK/ERK pathway inhibition with PD0325901, combined with pluripotency-supporting pathway modulation, promoted reprogramming toward a ground-state pluripotent stem cell identity.
Lin et al. (2009), Nature Methods
- Study describes a small-molecule reprogramming platform using PD0325901, SB431542 (Cat No. TB46416) and Thiazovivin (Cat No. TB75623) that improved human fibroblast iPSC generation efficiency by approximately 200-fold.
Nichols et al. (2009), Development
- Study describes that suppression of ERK signaling, including use of PD0325901 with CHIR99021 (Cat No. TB54925), supports pluripotent epiblast/ES cell derivation and helps shield pluripotent cells from differentiation-inducing signaling.
