Description
Technical Information & Resources
Supporting Publications
Young et al. (2015), Annu Rev Nutr
- Reviews ascorbate as a cofactor for TET dioxygenases and JmjC histone demethylases, linking cellular redox status to DNA and histone demethylation.
Esteban et al. (2010), Cell Stem Cell
- Shows vitamin C improves the speed and efficiency of mouse and human iPSC generation, in part by alleviating senescence, and promotes the transition of pre-iPSCs to a fully reprogrammed state.
Blaschke et al. (2013), Nature
- In mouse ES cells, vitamin C boosted Tet activity, rapidly raising 5hmC and driving DNA demethylation and a blastocyst-like state. Other antioxidants had no effect, and the response was lost in Tet1/Tet2-deficient cells.
