TrailBio® Dorsomorphin

$140.00

Small-molecule BMP inhibitor

  • Inhibits the BMP type I receptors ALK2, ALK3 and ALK6, blocking SMAD1/5/8 phosphorylation and BMP-driven gene transcription.
  • Stable and cost-effective small molecule alternative to protein antagonists such as Noggin.
  • Paired with SB-431542, can drive efficient neural induction from human ESCs and iPSCs.
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Description

Technical Information & Resources

Supporting Publications

Yu et al. (2008), Nat Chem Biol

  • Identified dorsomorphin as the first small-molecule BMP inhibitor. It blocks the BMP type I receptors ALK2, ALK3 and ALK6, and so prevents BMP-driven SMAD1/5/8 phosphorylation and target gene transcription.

Hao et al. (2008), PLoS One

  • Demonstrated that treating mouse ES cells with dorsomorphin strongly induced cardiomyocytes.

Morizane et al. (2011), J Neurosci Res

  • Showed that dorsomorphin combined with SB431542 gave highly efficient neural induction from human ESCs and iPSCs.

Additional information

Chemical Name

6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine

CAS Number

866405-64-3

Purity

≥98%

Formula

C24H25N5O

Molecular Weight

399.49 g/mol

Usage

For research use only

Storage (Solid)

4 °C for up to 2 years, protect from light

Storage (Solution)

-80 °C for up to 2 years or -20 °C for up to 1 year, protect from light

Form

Powder

Shipping

Ambient temperature