TrailBio Forskolin

TrailBio® Forskolin

$100.00

Adenylyl cyclase activator for cAMP signaling workflows 

  • Cell-permeable diterpene used to activate adenylyl cyclase and increase intracellular cAMP levels.
  • Supports research involving GPCR/G protein signaling, cAMP pathway modulation, metabolic enzyme/protease activity, Wnt/β-catenin, TGF-β/Smad, and organoid workflows.
  • Reported to activate PXR and FXR, supporting nuclear receptor and metabolic signaling research workflows.
Bulk, Academic or Special Pricing
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Description

Technical Information & Resources

Publications

Additional Information

Technical Information & Resources

Supporting Publications

Seamon et al. (1981), PNAS

  • Foundational paper identified Forskolin as a unique diterpene activator of adenylyl cyclase in membrane preparations and intact cells, supporting its use as a direct cAMP-elevating small molecule.

Awad et al. (1983), Journal of Biological Chemistry

  • This paper examined the interaction between Forskolin and adenylyl cyclase, supporting its role as a direct modulator of adenylyl cyclase activity.

Rodriguez et al. (2013), Journal of Biological Chemistry

  • This paper shows that Forskolin-induced cAMP signaling reduces human T-cell proliferation, with Forskolin increasing intracellular cAMP approximately 5- to 20-fold above basal levels in cell-based assays.

Additional information

Also Known As

Coleonol; Colforsin; Colforsina
Chemical Name

[(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate
CAS Number

66575-29-9
Purity

≥98%
Formula

C22H34O7
Molecular Weight

410.50 g/mol
Usage

For research use only
Storage (Solid)

4 °C, for up to 2 years, protect from light
Storage (Solution)

-80 °C for up to 6 months or -20 °C for up to 1 month, protect from light
Form

Powder
Shipping

Ambient temperature

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