TrailBio® TTNPB

$160.00

Potent, Metabolically Stable RAR Agonist

  • Synthetic arotinoid that binds and activates RARα/β/γ with low-nanomolar potency.
  • Engages RAREs to drive transcriptional activation with greater metabolic stability than endogenous RA, resisting oxidative isomerization.
  • Used in applications including chemical reprogramming to iPSCs, RAR-driven differentiation protocols, and retinoid structure-activity studies.
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Description

Technical Information & Resources

Supporting Publications

Beard et al. (1995), J Med Chem

  • This publication characterizes TTNPB’s structural basis for potent, selective RAR (vs. RXR) activation.

Keeble et al. (1989), Dev Biol

  • Early characterization showing TTNPB is ≥100x more potent than RA and binds CRABP with higher affinity.

Hou et al. (2013), Science

  • TTNPB used as one of the small molecules in a chemical reprogramming cocktail generating iPSCs without genetic factors (CiPSCs).

Additional information

Chemical Name

4-[(1E)-2-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl]benzoic acid

CAS Number

71441-28-6

Purity

≥98%

Formula

C24H28O2

Molecular Weight

348.48 g/mol

Usage

For research use only

Storage (Solid)

4 °C for up to 2 years, protect from light

Storage (Solution)

-80 °C for up to 6 months or -20 °C for up to 1 month; protect from light

Form

Powder

Shipping

Ambient temperature