TrailBio^® Purmorphamine

Wu et al. (2002), JACS

• This paper first identified and named purmorphamine, a 2,6,9-trisubstituted purine compound discovered through cell-based high-throughput screening of a heterocycle combinatorial library.

Sinha et al. (2006), Nature Chemical Biology

• This paper demonstrated that purmorphamine directly targets Smoothened, a critical transmembrane component of the Hedgehog signaling pathway, resolving the previously unknown mechanism behind its osteoblast-differentiation activity.

Hu et al. (2009), Nature Protocols

• This protocol paper explicitly describes using purmorphamine as a direct substitute for recombinant SHH protein to specify OLIG2-expressing motor neuron progenitors from human ESCs and iPSCs.