TrailBio® Hydrocortisone

$130.00

Natural glucocorticoid receptor agonist 

  • Identical to endogenous cortisol; binds and activates the glucocorticoid receptor (GR/NR3C1). 
  • Regulates glucocorticoid-responsive gene expression and modulates NF-κB and AP-1 inflammatory signaling. 
  • Used to study glucocorticoid signaling in immune, inflammatory, metabolic and stress responses, and in erythroid differentiation and endothelial barrier culture. 
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Description

Technical Information & Resources

Supporting Publications

Rhen & Cidlowski (2005), N Engl J Med 

  • Reviews how glucocorticoids act through the glucocorticoid receptor on multiple signaling pathways to resolve inflammation, including repression of pro-inflammatory transcription factors. 

Lapillonne et al. (2010), Haematologica 

  • Reports the first complete differentiation of human iPSCs into enucleated red blood cells, using a two-step, animal-protein-free, cytokine-based protocol. 

Förster et al. (2008), J Physiol 

  • In human brain microvascular endothelial cells (hCMEC/D3), glucocorticoid treatment raised occludin and claudin-5 expression and increased barrier tightness more than threefold, while hydrocortisone protected against TNFα-induced barrier breakdown. 

Additional information

Chemical Name

pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11β)-

CAS Number

50-23-7

Purity

≥98%

Formula

C21H30O5

Molecular Weight

362.46 g/mol

Usage

For research use only

Storage (Solid)

4 °C for up to 2 years, protect from light

Storage (Solution)

-80 °C for up to 6 months or -20 °C for up to 1 month, protect from light

Form

Powder

Shipping

Ambient temperature