TrailBio^® L-Ascorbic Acid

Young et al. (2015), Annu Rev Nutr 

• Reviews ascorbate as a cofactor for TET dioxygenases and JmjC histone demethylases, linking cellular redox status to DNA and histone demethylation. 

Esteban et al. (2010), Cell Stem Cell 

• Shows vitamin C improves the speed and efficiency of mouse and human iPSC generation, in part by alleviating senescence, and promotes the transition of pre-iPSCs to a fully reprogrammed state. 

Blaschke et al. (2013), Nature 

• In mouse ES cells, vitamin C boosted Tet activity, rapidly raising 5hmC and driving DNA demethylation and a blastocyst-like state. Other antioxidants had no effect, and the response was lost in Tet1/Tet2-deficient cells.