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Trailhead Biosystems, Inc. offers committed iPSC-derived oligodendrocytes, providing the opportunity for investigations of functional myelination in neural co-culture, drug discovery for leukodystrophies, and human disease modeling, and more.

Cells of the oligodendrocyte lineage play a key role in multiple disease states and serve as the major insulating cell type of the brain. Oligodendrocyte loss is observed in multiple sclerosis and is primarily due to autoimmune destruction, and this loss of oligodendrocyte number, or function, can lead to leukodystrophies; a typically fatal condition, prefigured by loss of sensory functions and motor activity.

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