TrailBio® Pre-Myelinating Oligodendrocytes Kit

5 X 10^6 cells/kit ($400/million)

Trailhead Biosystems^® offers committed iPSC-derived pre-myelinating oligodendrocytes, providing the opportunity to study cell-cell interactions in co-culture with neurons and/or astrocytes, drug discovery and human disease modeling of neurological diseases in which glial progenitors are affected. Cells of the oligodendrocyte lineage play a key role in multiple disease states and serve as the major insulating cell type of the brain. Oligodendrocyte loss is observed in multiple sclerosis, primarily due to autoimmune destruction. This loss of oligodendrocyte number or function can lead to leukodystrophies, a typically fatal condition that results in loss of sensory functions and motor activity.

Using our proprietary HD-DoE^® (High-dimensional design-of-experiments) technology, we created a multi-stage protocol resulting in rapid (20 days) and homogenous induction of pre-myelinating oligodendrocytes that can adopt a committed oligodendrocyte fate.